Pharmacology and molecular biology of octopamine receptors from different insect species.

@article{Roeder1995PharmacologyAM,
  title={Pharmacology and molecular biology of octopamine receptors from different insect species.},
  author={Thomas Roeder and J Degen and C. Dyczkowski and Michael Gewecke},
  journal={Progress in brain research},
  year={1995},
  volume={106},
  pages={
          249-58
        }
}
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21 Citations
Highly Influential Citations
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Background Citations
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21 Citations

A Novel Octopamine Receptor with Preferential Expression inDrosophila Mushroom Bodies
TLDR
The preferential expression of OAMB in mushroom bodies and its capacity to produce cAMP accumulation suggest an important role in synaptic modulation underlying behavioral plasticity.
Insect octopamine receptors: a new classification scheme based on studies of cloned Drosophila G-protein coupled receptors
TLDR
In future studies on the molecular basis of octopamine signalling in individual tissues it will be essential to identify the relative expression levels of the different classes ofOctopamine receptor present to identify if co-expression of such receptors in the same cells results in the formation of oligomeric receptors with specific emergent pharmacological and signalling properties.
Molecular and pharmacological analysis of an octopamine receptor from American cockroach and fruit fly in response to plant essential oils.
  • E. Enan
  • Biology
    Archives of insect biochemistry and physiology
  • 2005
TLDR
Competitive binding data and toxicity data suggest a correlation between cellular changes induced by tested plant essential oils and their toxicity against fruit fly and American cockroach.
Trace amine-associated receptor 1-Family archetype or iconoclast?
  • D. Grandy
  • Biology
    Pharmacology & therapeutics
  • 2007
Perturbation of tyraminergic/octopaminergic function inhibits oviposition in the cattle tick Rhipicephalus (Boophilus) microplus.
Octopamine receptor OAMB is required for ovulation in Drosophila melanogaster.
Effects of octopamine on lipolysis, glucose transport and amine oxidation in mammalian fat cells.
Stimulation and Attenuation Effects of Neuroactive Amines oncAMP Production in Two-spotted Mites Membranes
TLDR
It’s found that DA, which has similar structure with octopamine except its m-hydroxyl group in the phenyl ring, could significantly inhibit the cAMP production at above 10mM concentration.
A family of octapamine receptors that specifically induce cyclic AMP production or Ca2+ release in Drosophila melanogaster
TLDR
The functional characterization of two genes from Drosophila melanogaster that encode unique receptors that display signature properties of native octopamine receptors are described.
Trace Amines and Their Receptors
TLDR
In the brain, TAAR1 acts as a rheostat of dopaminergic, glutamatergic, and serotonergic neurotransmission and has been identified as a novel therapeutic target for schizophrenia, depression, and addiction, and in the periphery,TAAR1 regulates nutrient-induced hormone secretion, suggesting its potential as a Novel therapeutic targets for diabetes and obesity.
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References

SHOWING 1-10 OF 29 REFERENCES
Characterization of a potent agonist of the insect octopamine-receptor-coupled adenylate cyclase
Development of a photoaffinity ligand for octopamine receptors.
Octapamine receptors are widely distributed in invertebrate species, yet little is known about their biochemical structure or tissue localization, in part because there exist no high affinity or…
Characterization of octopamine-sensitive adenylate cyclase: elucidation of a class of potent and selective octopamine-2 receptor agonists with toxic effects in insects.
  • J. Nathanson
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1985
TLDR
Because octopamine-2 receptors appear to be present primarily in invertebrates, these findings raise the possibility that potent and selectiveOctopamine agonists could be useful as insect toxins with low toxicity in vertebrates.
High-affinity antagonists of the locust neuronal octopamine receptor.
  • T. Roeder
  • Biology
    European journal of pharmacology
  • 1990
Multiple receptor types for octopamine in the locust.
  • P. Evans
  • Biology
    The Journal of physiology
  • 1981
TLDR
The results are discussed in terms of the location of the various classes of octopamine receptors, their possible relationship to vertebrate alpha‐adrenoreceptors, and the significance of the results for studies on octopamines receptors in the vertebrate central nervous system.
Pharmacological characterization of octopamine-sensitive adenylate cyclase in the flight muscle of Locusta migratoria L.
Pharmacological properties of octopamine-2 receptors in locust neuroendocrine tissue
A new octopamine receptor class in locust nervous tissue, the octopamine 3 (OA3) receptor.
Phenyliminoimidazolidine Derivatives Activate Both Octopamine1 and Octopamine2 Receptor Subtypes in Locust Skeletal Muscle
TLDR
The actions of the phenyliminoimidazolidine derivatives, NC7 and NC5 on octopamine receptors in the extensor-tibiae neuromuscular preparation of the locust are described, suggesting they may be useful in the development of selective agonists that can distinguish between the different pharmacological subclasses ofOctopamine receptor.
Octopamine in insects: neurotransmitter, neurohormone, and neuromodulator
TLDR
It is shown that octopamine can act as a neurotransmitter, a neurohormone, and a neuromodulator within the nervous system of invertebrates and in locusts, an identified octopaminergic neuron innervates the extensor-tibiae muscle of the hind legs.
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