Pharmacology and mechanisms of opioid analgesic activity.

  title={Pharmacology and mechanisms of opioid analgesic activity.},
  author={Tony L. Yaksh},
  journal={Acta anaesthesiologica Scandinavica},
  volume={41 1 Pt 2},
  • Tony L. Yaksh
  • Published 1997 in Acta anaesthesiologica Scandinavica
Opiates by an action at specific receptors can induce a highly selective alteration in the response of humans and animals to strong and otherwise aversive chemical, mechanical or thermal stimuli. Specific investigations in a variety of species from rodent to primate using microinjection techniques to examine the pharmacology of local drug action have shown potent antinociceptive actions to be mediated by a receptor specific action at a number of sites within the brain, including the… CONTINUE READING


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