Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

@article{Ansell2008PharmacologyAM,
  title={Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).},
  author={Jack Ansell and Jack Hirsh and Elaine M. Hylek and Agneta Jacobson and Mark Andrew Crowther and Gualtiero Palareti},
  journal={Chest},
  year={2008},
  volume={133 6 Suppl},
  pages={160S-198S}
}
This article concerning the pharmacokinetics and pharmacodynamics of vitamin K antagonists (VKAs) is part of the American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). It describes the antithrombotic effect of the VKAs, the monitoring of anticoagulation intensity, and the clinical applications of VKA therapy and provides specific management recommendations. Grade 1 recommendations are strong and indicate that the benefits do or do not outweigh the risks… CONTINUE READING
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