Pharmacology and functions of metabotropic glutamate receptors.

  title={Pharmacology and functions of metabotropic glutamate receptors.},
  author={P Jeffrey Conn and Jean Philippe Pin},
  journal={Annual review of pharmacology and toxicology},
In the mid to late 1980s, studies were published that provided the first evidence for the existence of glutamate receptors that are not ligand-gated cation channels but are coupled to effector systems through GTP-binding proteins. Since those initial reports, tremendous progress has been made in characterizing these metabotropic glutamate receptors (mGluRs), including cloning and characterization of cDNA that encodes a family of eight mGluR subtypes, several of which have multiple splice… CONTINUE READING
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