Pharmacology and electrophysiology of a synchronous GABA-mediated potential in the human neocortex.

@article{Avoli1994PharmacologyAE,
  title={Pharmacology and electrophysiology of a synchronous GABA-mediated potential in the human neocortex.},
  author={Massimo Avoli and Donatella Mattia and Antonio Siniscalchi and Pierre Perreault and Francesco Tomaiuolo},
  journal={Neuroscience},
  year={1994},
  volume={62 3},
  pages={655-66}
}
Spontaneous synchronous field potentials of negative polarity (duration = 200-700 ms, inter-event interval = 9.1 +/- 2.9 s; n = 27 slices) were recorded, during application of 4-aminopyridine (50 microM), from the superficial/middle layers of slices of human neocortex obtained in the course of neurosurgery for the relief of intractable seizures. The negative-going field potential corresponded to an intracellular long-lasting (duration = 200-1600 ms) depolarization that could be preceded by… CONTINUE READING