Pharmacology and Optimization of Thiopurines and Methotrexate in Inflammatory Bowel Disease.

@article{Coskun2016PharmacologyAO,
  title={Pharmacology and Optimization of Thiopurines and Methotrexate in Inflammatory Bowel Disease.},
  author={Mehmet Erdal Coskun and Casper Steenholdt and Nanne K. H. de Boer and Ole Haagen Nielsen},
  journal={Clinical pharmacokinetics},
  year={2016},
  volume={55 3},
  pages={257-74}
}
Improving the efficacy and reducing the toxicity of thiopurines and methotrexate (MTX) have been areas of intense basic and clinical research. An increased knowledge on pharmacodynamics and pharmacokinetics of these immunomodulators has optimized treatment strategies in inflammatory bowel disease (IBD). This review focuses on the metabolism and mode of… CONTINUE READING