Pharmacologie du tramadol

@article{Dayer2012PharmacologieDT,
  title={Pharmacologie du tramadol},
  author={Pierre Dayer and Jules Alexandre Desmeules and L. Collart},
  journal={Drugs},
  year={2012},
  volume={53},
  pages={18-24}
}
RésuméLe (±)-tramadol est un analgésique central à faible affinité pour les récepteurs opiacés. Le taux de production de son métabolite M1 (O-déméthyl tramadol), de manière analogue à la codéine, est contrôlé par le polymorphisme génétique de type débrisoquine (CYP2D6) et le dérivé M1 présente, par rapport à la molécule mère, une plus forte affinité pour les récepteurs opiacés. Des données expérimentales et cliniques indiquent que le tramadol exerce aussi son effet antalgique par une action au… 
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TLDR
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TLDR
Although more studies are needed to provide clear guidance on the opioid of choice, tapentadol shows some advantages, as it does not require CYP450 system activation and has minimal serotonergic effects, which leads to less side effects and lower abuse liability.
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TLDR
The combination of monoamine and opioid mechanisms opens new avenues for the design of innovative analgesic drugs to treat moderate to severe pain.
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La combinacion ensayada produjo una adecuada analgesia sin causar alteraciones hemodinamicas y respiratorias re­levantes, asi asi tambien establecer la calidad y el tiempo of recuperacion.
ADME and toxicity considerations for tramadol: from basic research to clinical implications
TLDR
This review provides a comprehensive view on the pharmacokinetic, pharmacodynamic, and toxicity of tramadol with a deep look on its side effects, biochemical and pathological changes, and possible drug interactions.
Capillary Electrophoresis Methods for the Determination of Tramadol: A Review
Tramadol is a widely used opioid analgesic frequently prescribed for treatment of moderate to severe, acute and chronic pain. It has a complex mechanism of action, acting both as a central opiate
Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6
TLDR
The parent-metabolite model successfully characterized the PK of tramadol and its metabolite M1 in healthy Korean male subjects and could be applied to evaluate plasma tramadl concentrations after various dosing regimens.
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TLDR
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