Pharmacologically regulated gene expression in the retina following transduction with viral vectors

@article{Dejneka2001PharmacologicallyRG,
  title={Pharmacologically regulated gene expression in the retina following transduction with viral vectors},
  author={Nadine S Dejneka and Alberto Auricchio and Albert M. Maguire and Xuehai Ye and G Gao and James Michael Wilson and Jean Bennett},
  journal={Gene Therapy},
  year={2001},
  volume={8},
  pages={442-446}
}
The availability of inducible expression systems makes regulatable control of therapeutic proteins an attainable goal in gene therapy. We delivered tetracycline-inducible transgenes to the subretinal space using recombinant adenoviruses. Upon administration of doxycycline, we demonstrated reversible expression of green fluorescent protein in the retinal pigment epithelium as well as modulation of human growth hormone produced in the retina and secreted in the blood stream. This mode of delivery… CONTINUE READING

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Recombinant adenovirus and ocular gene therapy

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