Pharmacologically induced angiogenesis in transgenic zebrafish.

  title={Pharmacologically induced angiogenesis in transgenic zebrafish.},
  author={Michael Raghunath and Yuan Sy Wong and Muhammad Ansar Farooq and Ruowen Ge},
  journal={Biochemical and biophysical research communications},
  volume={378 4},
The rapid vascularisation of biomaterials and engineered tissue after implantation is a current unmet need. To this end, we explored the pharmacological option of inducing neovascularisation using compounds that inhibit hypoxia-induced factor-1alpha prolyl hydroxylase. This stabilises hypoxia inducible factor-1alpha and therefore de-repress the transcription of various angiogenic genes. In the quest for a small vertebrate model allowing for in vivo screening we exposed (TG(Fli1:EGFP… CONTINUE READING


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