Pharmacologically different Na/H antiporters on the apical and basolateral surfaces of cultured porcine kidney cells (LLC-PK1).

@article{Haggerty1988PharmacologicallyDN,
  title={Pharmacologically different Na/H antiporters on the apical and basolateral surfaces of cultured porcine kidney cells (LLC-PK1).},
  author={John G. Haggerty and Neeraj Agarwal and Robert F. Reilly and Edward A. Adelberg and Carolyn W. Slayman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 18},
  pages={6797-801}
}
Proximal tubule cells of the kidney contain, on their apical surface, an amiloride-sensitive Na/H antiporter that functions in Na reabsorption and proton secretion. We have investigated the localization of the antiporter in a cloned cell line of porcine renal origin, LLC-PK1/Cl4, which is often considered to be a useful model of the proximal tubule. Transport measurements were performed with differentiated monolayers grown on Nuclepore filters, permitting independent access to the apical and… CONTINUE READING
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