Pharmacological validation of a refined burrowing paradigm for prediction of analgesic efficacy in a rat model of sub-chronic knee joint inflammation.

@article{Rutten2014PharmacologicalVO,
  title={Pharmacological validation of a refined burrowing paradigm for prediction of analgesic efficacy in a rat model of sub-chronic knee joint inflammation.},
  author={Kris Rutten and Angela Robens and Simon James Read and Thomas Christoph},
  journal={European journal of pain},
  year={2014},
  volume={18 2},
  pages={
          213-22
        }
}
BACKGROUND Burrowing is an evolutionarily conserved behaviour in rodents. This study validates a refined burrowing paradigm (requiring a reduced number of animals) in a rat model of sub-chronic knee joint inflammation and evaluates its sensitivity and specificity for analgesic drugs. METHODS Knee joint inflammation in rats was induced by intra-articular injection with complete Freund's adjuvant (CFA). Burrowing performance was assessed at baseline without study drugs, and in CFA-naive and CFA… CONTINUE READING

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