Pharmacological uncoupling of activation induced increases in CBF and CMRO2.

  title={Pharmacological uncoupling of activation induced increases in CBF and CMRO2.},
  author={Christoph Leithner and Georg Royl and Nikolas Offenhauser and Martina F{\"u}chtemeier and Matthias Kohl-Bareis and Arno Villringer and Ulrich Dirnagl and Ute Lindauer},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={30 2},
Neurovascular coupling provides the basis for many functional neuroimaging techniques. Nitric oxide (NO), adenosine, cyclooxygenase, CYP450 epoxygenase, and potassium are involved in dilating arterioles during neuronal activation. We combined inhibition of NO synthase, cyclooxygenase, adenosine receptors, CYP450 epoxygenase, and inward rectifier potassium (Kir) channels to test whether these pathways could explain the blood flow response to neuronal activation. Cerebral blood flow (CBF) and… CONTINUE READING