Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors

@inproceedings{Im2010PharmacologicalTF,
  title={Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors},
  author={Dong-soon Im},
  booktitle={Acta Pharmacologica Sinica},
  year={2010}
}
AbstractPrevious studies on lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) using various approaches have shown that both the molecules can act as intercellular signaling molecules. The discovery of the Edg subfamily of G-protein-coupled receptors (GPCRs) (later renamed LPA1–3 and S1P1–5) for these molecules has opened up a new avenue for pathophysiological research on lysophospholipids. Genetic and molecular studies on lysophospholipid GPCRs have elucidated pathophysiological… CONTINUE READING
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