Pharmacological targeting of the mitochondrial phosphatase PTPMT1.

  title={Pharmacological targeting of the mitochondrial phosphatase PTPMT1.},
  author={Dahlia Doughty-Shenton and James D Joseph and Ji Zhang and David J Pagliarini and Youngjun Kim and Danhong Lu and Jack E. Dixon and Patrick J. Casey},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={333 2},
The dual-specificity protein tyrosine phosphatases (PTPs) play integral roles in the regulation of cell signaling. There is a need for new tools to study these phosphatases, and the identification of inhibitors potentially affords not only new means for their study, but also possible therapeutics for the treatment of diseases caused by their dysregulation. However, the identification of selective inhibitors of the protein phosphatases has proven somewhat difficult. PTP localized to… CONTINUE READING
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