Pharmacological targeting of glucagon and glucagon-like peptide 1 receptors has different effects on energy state and glucose homeostasis in diet-induced obese mice.

Abstract

Pharmacologic contributions of directly agonizing glucagon-like peptide 1 (GLP-1) receptor or antagonizing glucagon receptor (GCGR) on energy state and glucose homeostasis were assessed in diet-induced obese (DIO) mice. Metabolic rate and respiratory quotient (RQ), hyperglycemic clamp, stable isotope-based dynamic metabolic profiling (SiDMAP) studies of (13… (More)
DOI: 10.1124/jpet.111.179986

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@article{Gu2011PharmacologicalTO, title={Pharmacological targeting of glucagon and glucagon-like peptide 1 receptors has different effects on energy state and glucose homeostasis in diet-induced obese mice.}, author={Wei Gu and David J. B. Lloyd and Narumol Chinookswong and Renee Komorowski and Glenn Sivits and Melissa L. Graham and Katherine Winters and Hai Yan and L{\'a}szl{\'o} G. Boros and Richard A. Lindberg and Murielle M V{\'e}niant}, journal={The Journal of pharmacology and experimental therapeutics}, year={2011}, volume={338 1}, pages={70-81} }