Pharmacological targeting of eIF4E in primary CLL lymphocytes

@inproceedings{MartinezMarignac2013PharmacologicalTO,
  title={Pharmacological targeting of eIF4E in primary CLL lymphocytes},
  author={Veronica L. Martinez-Marignac and May Shawi and E Pinedo-Carpio and Xian-ren Wang and Lawrence Panasci and Wilson H. Miller and Filippa Pettersson and Raquel S. Aloyz},
  booktitle={Blood cancer journal},
  year={2013}
}
Eukaryotic translation initiation factor 4E (eIF4E) is a rate-limiting factor for cap-dependent protein synthesis regulated by the PI3K/ AKT/mTOR signaling pathway as well as MNK1/2-mediated phosphorylation. In addition to its cytoplasmic functions in translation, nuclear eIF4E aids in the cytoplasmic export of specific mRNAs. eIF4E is overexpressed in many cancers and has been reported to have important roles in the development and progression of hematological malignancies in animal models… CONTINUE READING

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