Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy

@inproceedings{Cuadrado2018PharmacologicalTO,
  title={Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy},
  author={Antonio Cuadrado and Sebastian K{\"u}gler and Isabel Lastres-Becker},
  booktitle={Redox biology},
  year={2018}
}
Tauopathies are a group of neurodegenerative disorders where TAU protein is presented as aggregates or is abnormally phosphorylated, leading to alterations of axonal transport, neuronal death and neuroinflammation. Currently, there is no treatment to slow progression of these diseases. Here, we have investigated whether dimethyl fumarate (DMF), an inducer of the transcription factor NRF2, could mitigate tauopathy in a mouse model. The signaling pathways modulated by DMF were also studied in… CONTINUE READING
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