Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

@inproceedings{OlmosAlonso2016PharmacologicalTO,
  title={Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology},
  author={Adrian Olmos-Alonso and Sjoerd T. T. Schetters and S. Sharmila Sri and Katharine E Askew and Renzo Mancuso and Mariana Vargas-Caballero and Christian H{\"o}lscher and V. Hugh Perry and Diego G{\'o}mez-Nicola},
  booktitle={Brain : a journal of neurology},
  year={2016}
}
The proliferation and activation of microglial cells is a hallmark of several neurodegenerative conditions. This mechanism is regulated by the activation of the colony-stimulating factor 1 receptor (CSF1R), thus providing a target that may prevent the progression of conditions such as Alzheimer's disease. However, the study of microglial proliferation in Alzheimer's disease and validation of the efficacy of CSF1R-inhibiting strategies have not yet been reported. In this study we found increased… CONTINUE READING

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