Pharmacological suppression of REM sleep prior to weaning counteracts the effectiveness of subsequent environmental enrichment on cortical growth in rats.

@article{Mirmiran1983PharmacologicalSO,
  title={Pharmacological suppression of REM sleep prior to weaning counteracts the effectiveness of subsequent environmental enrichment on cortical growth in rats.},
  author={Majid Mirmiran and H. B. M. Uylings and Michael A. Corner},
  journal={Brain research},
  year={1983},
  volume={283 1},
  pages={102-5}
}
Male Wistar rat pups were deprived of REM sleep by means of daily injections of clonidine between 8 and 21 days after birth. From day 28 they were reared under either 'enriched' or 'standard' environmental conditions. At 75 days of age the animals were sacrificed, and the regional brain weights were compared with two (differentially reared) control groups… CONTINUE READING