Pharmacological study on angusticeps-type toxins from mamba snake venoms.

  title={Pharmacological study on angusticeps-type toxins from mamba snake venoms.},
  author={Chang Yeob Lee and M. C. Tsai and M L Tsaur and Wen Wei Lin and F H Carlsson and F. J. Joubert},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={233 2},
Five angusticeps-type toxins, F7, F8 and C10S2C2 from Dendroaspis angusticeps and C and FS2 from D. polylepis polylepis, were tested for action on the chick biventer cervicis nerve-muscle, the frog rectus abdominis muscle and the mouse phrenic nerve-diaphragm preparations. In the chick muscle, none of these toxins exhibited any stimulatory effect up to 100 micrograms/ml. In the frog muscle, the response to acetylcholine, but not to carbachol, was enhanced dose dependently by F7 and C. No… CONTINUE READING