Pharmacological studies on nonimmunologic contact urticaria in guinea pigs

@article{Lahti1986PharmacologicalSO,
  title={Pharmacological studies on nonimmunologic contact urticaria in guinea pigs},
  author={Arto Lahti and Denise McDonald and Raija H. Tammi and Howard Ira Maibach},
  journal={Archives of Dermatological Research},
  year={1986},
  volume={279},
  pages={44-49}
}
In the present study we examined the effects of chlorpheniramine and ranitidine, indomethacin, BW755C (an inhibitor of cyclo-oxygenase and lipooxygenase enzymes of arachidonic acid metabolism), dexamethasone, and capsaicin on nonimmunologic contact urticaria (NICU) induced in the guinea pig ear by benzoic acid, cinnamic acid, cinnamic aldehyde, methyl nicotinate, diethyl fumarate, or dimethyl sulfoxide. The intensity of edema in the urticarial reaction was quantified by measuring the ear… CONTINUE READING
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