Corpus ID: 20188527

Pharmacological studies on a new dihydrothienopyridine calcium antagonist. 1st communication: comparative studies on the cardiovascular effects of methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2,3- b]pyridine-5-carboxylate and its two enantiomers in experimental animals.

@article{Ueda1993PharmacologicalSO,
  title={Pharmacological studies on a new dihydrothienopyridine calcium antagonist. 1st communication: comparative studies on the cardiovascular effects of methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2,3- b]pyridine-5-carboxylate and its two enantiomers in experimental animals.},
  author={M. Ueda and S. Matsumura and M. Masui and E. Matsuura and O. Uno and M. Kawakami and M. Ninomiya and I. Adachi},
  journal={Arzneimittel-Forschung},
  year={1993},
  volume={43 12},
  pages={
          1270-5
        }
}
Antihypertensive effects in conscious spontaneously hypertensive rats (SHR), cardiovascular effects in anesthetized dogs, and calcium antagonistic effects in the rabbit isolated basilar arteries and guinea-pig isolated coronary arteries of S-312 (methyl-4,7-dihydro-3-isobutyl-6-methyl-4- (3-nitrophenyl) thieno [2,3-b] pyridine-5-carboxylate) and its two enantiomers were comparatively investigated. The antihypertensive effect in SHR and hypotensive effect in anesthetized dogs of S-312-d (CAS… Expand
2 Citations
Pharmacological studies on a new dihydrothienopyridine calcium antagonist, S-312-d. 5th communication: anticonvulsant effects in mice.
TLDR
Although moderate anticonvulsant effects of S-312-d in higher doses were observed against the clonic convulsions induced by pentylenetetrazole or bemegride, no effects were observed in convulsion induced by N-methyl-D-aspartate, picrotoxin, or electroshock in Slc:ddY mice. Expand
Synthesis of 3-Unsubstituted 4-Aryl-4,7-Dihydrothieno[2,3-b]Pyridine-2,5-Dicarboxylates / 3-Neaizvietotu 4-Aril-4,7-Dihidrotiēno[2,3-B]Piridīn-2,5-Dikarbonskābes Esteru Sintēze
Novel 3-unsubstituted 4,7-dihydrothieno[2,3-b]pyridines were prepared by heterocyclization of methyl acetoacetate, an aromatic aldehyde and Meldrum’s acid in the presence of ammonium acetate inExpand