Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review

@article{Geyer2001PharmacologicalSO,
  title={Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review},
  author={Mark A. Geyer and Kirsten Krebs-Thomson and David L. Braff and Neal R. Swerdlow},
  journal={Psychopharmacology},
  year={2001},
  volume={156},
  pages={117-154}
}
Abstract.Rationale: Patients with schizophrenia exhibit deficits in an operational measure of sensorimotor gating: prepulse inhibition (PPI) of startle. Similar deficits in PPI are produced in rats by pharmacological or developmental manipulations. These experimentally induced PPI deficits in rats are clearly not animal models of schizophrenia per se, but appear to provide models of sensorimotor gating deficits in schizophrenia patients that have face, predictive, and construct validity. In… CONTINUE READING

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