Pharmacological strategies for overcoming multidrug resistance.

  title={Pharmacological strategies for overcoming multidrug resistance.},
  author={Stefania Nobili and Ida Landini and Barb{\'a}ra Giglioni and Enrico Mini},
  journal={Current drug targets},
  volume={7 7},
Multidrug resistance (MDR) is a major obstacle to the effective treatment of cancer. One of the underlying mechanisms of MDR is cellular overproduction of P-glycoprotein (P-gp) which acts as an efflux pump for various anticancer drugs. P-gp is encoded by the MDR1 gene and its overexpression in cancer cells has become a therapeutic target for circumventing multidrug resistance. A potential strategy is to co-administer efflux pump inhibitors, although such reversal agents might actually increase… CONTINUE READING