Pharmacological reduction of brain edema induced by intracarotid infusion of protamine sulphate: a comparison between a free radical scavenger and an AMPA receptor antagonist.

@article{Johansson1994PharmacologicalRO,
  title={Pharmacological reduction of brain edema induced by intracarotid infusion of protamine sulphate: a comparison between a free radical scavenger and an AMPA receptor antagonist.},
  author={B H Brusheim Johansson and Irena Westergren},
  journal={Acta neurochirurgica. Supplementum},
  year={1994},
  volume={60},
  pages={
          128-31
        }
}
The blood-brain barrier (BBB) of rats was opened by infusing 10 mg protamine sulphate (200 microliters in 30 s) into the right internal carotid artery. Ten minutes later, tirilazad, a 21-aminosteroid (3 mg/kg): NBQX, an AMPA receptor antagonist (5 mg/kg); or dixyrazine, a phenotiazine derivate (10 mg/kg), was administered intravenously and the rats were killed 2 h after protamine infusion. Brain specific gravity was determined in the frontal, parietal and occipital cortex and in the striatum… CONTINUE READING