Pharmacological protection of hearing loss in the mouse model of endolymphatic hydrops.

Abstract

OBJECTIVES/HYPOTHESIS Excitotoxic and related inflammatory injury are implicated in the spiral ganglion degeneration seen with Meniere's disease and endolymphatic hydrops (ELH). Excitotoxicity is initiated with glutamate elevation and associated with downstream increases in reactive oxygen species resulting in inflammation-mediated neuronal degeneration… (More)
DOI: 10.1002/lary.21018

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