Pharmacological properties of trimebutine and N-monodesmethyltrimebutine.

  title={Pharmacological properties of trimebutine and N-monodesmethyltrimebutine.},
  author={François J. Roman and S Lanet and Jacques Hamon and G K Brunelle and Arnaud Maurin and P. Champeroux and Sabine Richard and Nicola Alessandri and Monica Gola},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={289 3},
Trimebutine [2-dimethylamino-2-phenylbutyl-3,4,5-trimethoxybenzoate hydrogen maleate (TMB)] has been demonstrated to be active for relieving abdominal pain in humans. To better understand its mechanism of action, we have tested TMB; nor-TMB, its main metabolite in humans; and their respective stereoisomers for their affinity toward sodium channels labeled by [3H]batrachotoxin, their effect on sodium, potassium, and calcium currents in rat dorsal root ganglia neurons, and their effect on… CONTINUE READING