Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent.

  title={Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent.},
  author={J. Patel and J. Malick},
  journal={European journal of pharmacology},
  volume={78 3},
  • J. Patel, J. Malick
  • Published 1982
  • Chemistry, Medicine
  • European journal of pharmacology
  • Tracazolate (ICI 136,753, 4-butylamino-1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester) demonstrated dose-related anticonflict activity in rats and mice. The potency of tracazolate appears to be one-quarter to one-half that of chlordiazepoxide. No tolerance to the anticonflict activity of either tracazolate or chlordiazepoxide was evident following 12 consecutive days of treatment. Tracazolate exhibits a much greater separation between sedative and therapeutic doses… CONTINUE READING
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