Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent.

@article{Patel1982PharmacologicalPO,
  title={Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent.},
  author={Jitendra B. Patel and Jeffrey B. Malick},
  journal={European journal of pharmacology},
  year={1982},
  volume={78 3},
  pages={
          323-33
        }
}
  • J. Patel, J. Malick
  • Published 12 March 1982
  • Biology, Psychology, Chemistry
  • European journal of pharmacology
Tracazolate: A novel nonsedative anxiolytic
TLDR
It is predicted that tracazolate will not be sedative at anxiolytic doses in man, and based upon studies in rodents, it should be much less likely than the benzodiazepines to potentiate the actions of barbiturates and ethanol in man.
Pharmacology of pyrazolopyridines
Preclinical studies with pyrazolopyridine non-benzodiazepine anxiolytics: ICI 190,622
Novel non-benzodiazepine anxiolytics
Effects of pyrazolopyridines and a triazolopyridazine on the pentobarbital discriminative stimulus
TLDR
While certain barbiturates, benzodiazepines, pyrazolopyridines, and triazolopyrsidazines are capable of producing similar stimulus effects, the behavioral actions of these agents can be differentiated on the basis of their susceptibility to antagonism by flumazepil.
Comparative neuropharmacology of antianxiety drugs
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 12 REFERENCES
Possible involvement of GABA in the central actions of benzodiazepines.
TLDR
It is concluded that benzodiazepines probably enhance presynaptic inhibition at all levels of the neuraxis and that this effect requires not only the presence of GABA but is also dependent on an activity of GABA-ergic neurons.
Comparative Anticonvulsive Action of 3,5,5-trimethyloxazolidine-2,4-dione (Tridione), Dilantin and Phenobarbital
TLDR
Comparative experiments with phenobarbital and dilantin revealed that tridione is more comparable to phenobarBital in its action but produces less depression in effective doses.
Effects of isoproterenol and chlordiazepoxide on drinking and conflict behaviors in rats
Cyclic Adenosine Monophosphate Phosphodiesterase in Brain: Effect on Anxiety
TLDR
Drugs that reduce anxiety may be mediated by cyclic adenosine monophosphate in the brain because there is a significant correlation between the anxiety-reducing property of drugs and their ability to inhibit phosphodiesterase activity in thebrain.
Acute and subacute effects of diazepam on psychomotor skills: interaction with alcohol.
TLDR
It is suggested that a development of tolerance to diazepam may compensate the deleterious interaction of the agents found in acute studies and be responsible for the improvement in psychomotor skills.
A simplified method of evaluating dose-effect experiments.
TLDR
The method provides means for the rapid test of parallelism of two curves and easy computation of relative potency with its confidence limits and its accuracy is commensurate with the nature of dose-per cent effect data.
...
1
2
...