Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent.

@article{Patel1982PharmacologicalPO,
  title={Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent.},
  author={J. Patel and J. Malick},
  journal={European journal of pharmacology},
  year={1982},
  volume={78 3},
  pages={
          323-33
        }
}
  • J. Patel, J. Malick
  • Published 1982
  • Chemistry, Medicine
  • European journal of pharmacology
    • Tracazolate (ICI 136,753, 4-butylamino-1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester) demonstrated dose-related anticonflict activity in rats and mice. The potency of tracazolate appears to be one-quarter to one-half that of chlordiazepoxide. No tolerance to the anticonflict activity of either tracazolate or chlordiazepoxide was evident following 12 consecutive days of treatment. Tracazolate exhibits a much greater separation between sedative and therapeutic doses… CONTINUE READING
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    57 Citations
    Background Citations
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    Results Citations
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    57 Citations
    Citation Type

    Citation Type

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    Novel non-benzodiazepine anxiolytics
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    Effects of pyrazolopyridines and a triazolopyridazine on the pentobarbital discriminative stimulus
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    Benzodiazepine-induced hyperphagia in the nondeprived rat: Comparisons with CL 218,872, zopiclone, tracazolate and phenobarbital
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    Adenosine receptor interactions and anxiolytics
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    Chapter 2. Anti-Anxiety Agents, Anticonvulsants, and Sedative-Hypnotics
    Comparative neuropharmacology of antianxiety drugs
    • 24

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