Pharmacological properties of the norepinephrine-induced depolarization of astrocytes in primary culture: evidence for the involvement of an alpha 1-adrenergic receptor.


The membrane potentials of astrocytes in primary cultures prepared from neonatal rat cerebral cortices were depolarized by (-)-norepinephrine. The average first response to 10(-5) M (-)-norepinephrine was 24 mV from an average resting potential of -68 mV, and the average for the second response was 14 mV. Thus this process showed marked desensitization. The… (More)


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