Pharmacological properties of some derivatives of 1,3-benzoxazine

@article{Bernardi2005PharmacologicalPO,
  title={Pharmacological properties of some derivatives of 1,3-benzoxazine},
  author={Luigi Rossi Bernardi and Sergio Coda and Lorenzo Pegrassi and Giselbert Karl Suchowsky},
  journal={Experientia},
  year={2005},
  volume={24},
  pages={774-775}
}
Sono stati studiati 22 derivati della 1,3-benzossazina, 8 dei quali sono risultati attivi sulla depressione da reserpina. Tra essi il più efficace è stato il 4H-3-carbossamidometil-1,3-benzossazin-2-one. Correlando la struttura chimica all'attività farmacologica si è visto che la distanza del gruppo amidico dall'anello benzossazinico, la linearità della catena, come pure la presenza di un gruppo amidico libero sono essenziali per l'esplicarsi dell'effetto. Anche sostituzioni in R4 o nell'anello… 

Fifty years of chemical research at Farmitalia.

This review contains a brief description of the chemistry developed in Farmitalia and, after 1978, Farmitalian-Carlo Erba Research Laboratories, during the second half of the last century, in the field of medicinal and natural product chemistry.

Ruthenium-Catalyzed Aminomethylation and Methylation of Phenol Derivatives Utilizing Methanol as the C1 Source

A reaction involving ortho-aminomethylation of phenol was developed via ruthenium-catalyzed dehydrogenation of methanol, an environmentally benign C1 building block, without the use of reactive

Xenobiotic–urea conjugates; chemical or biological?

  • S. Mitchell
  • Chemistry
    Xenobiotica; the fate of foreign compounds in biological systems
  • 2014
Data gleaned from the literature concerning xenobiotic–urea conjugation is collated, pertinent information resurrecting the controversy is presented, and questions as to the nature of the phenomenon are posed.

References

SHOWING 1-2 OF 2 REFERENCES

Interactions between reserpine, chlorpromazine, and imipramine

L'effetto sedativo della cloropromazina è più marcato di quello della imipramina ed è sinergico con the depressione indotta dalla reserpina.

ON THE MECHANISM OF ANTIDEPRESSANT ACTION OF IMIPRAMINELIKE DRUGS

The present studies show that imipramine counteracts and even reverses the sedation and other central effects of reserpine and of Ro-4-1284, a synthetic benzoquinolizine, without influencing their release of brain amines, and suggest that the reserpinelike syndrome might serve as a useful tool in studies of the antidepressant action of imIPraminelike compounds.