Pharmacological properties of shikonin - a review of literature since 2002.

@article{Andujar2013PharmacologicalPO,
  title={Pharmacological properties of shikonin - a review of literature since 2002.},
  author={Isabel Anduj́ar and Jos{\'e} Luis R{\'i}os and Rosa Mar{\'i}a Giner and Mar{\'i}a del Carmen Recio},
  journal={Planta medica},
  year={2013},
  volume={79 18},
  pages={
          1685-97
        }
}
The naphthoquinone shikonin is the main active principle of Zicao, a traditional Chinese herbal medicine made from the dried root of Lithospermum erythrorhizon. Studies carried out over the past 30 years have provided a scientific basis for the use of Zicao which has been long employed in folk medicine to treat a variety of inflammatory and infectious diseases. In particular, shikonin has been shown to possess many diverse properties, including antioxidant, anti-inflammatory, antithrombotic… 

Figures and Tables from this paper

Anticancer , Antimicrobial and other Pharmacological Properties of Shikonin and its Derivatives
TLDR
The aim of this review is to provide an updated data published on antimicrobial, anticancer activities, and other health properties of shikonin and their derivatives.
Shikonin: a review with a focus on anti-inflammatory and anticancer mechanisms
TLDR
This feature appears to enable shikonin to regulate the cell fate in a manner dependent on the cell context and experimental setting, which may provide insights into the mechanisms by which cells integrate the ROS signaling in the decision of the cellular outcome, such as survival, autophagy and apoptosis.
Synthesis of Novel Shikonin Derivatives and Pharmacological Effects of Cyclopropylacetylshikonin on Melanoma Cells
Despite much research in the last centuries, treatment of malignant melanoma is still challenging because of its mostly unnoticeable metastatic spreading and aggressive growth rate. Therefore, the
Antinociceptive properties of shikonin: in vitro and in vivo studies.
TLDR
The mechanistic role of shikonin on pain modulation, predominantly via sodium channel modulation, is unveiled, suggesting that shik onin could be developed as a potential pain blocker.
Medicinal Plants and Isolated Molecules Demonstrating Immunomodulation Activity as Potential Alternative Therapies for Viral Diseases Including COVID-19
TLDR
The immunomodulation potential of certain plants along with their bioactive chemical constituents are described and highlighted to highlight the potential for therapy for the management of infectious diseases, including viral ones such as COVID-19.
Biotechnological approaches to the production of shikonins: a critical review with recent updates
TLDR
Different methods of increasing the levels of shikonins in plant cells such as selection of cell lines, optimization of culture conditions, elicitation, in situ product removal, genetic transformation and metabolic engineering are discussed.
Metabolic profiling study of shikonin's cytotoxic activity in the Huh7 human hepatoma cell line.
TLDR
The potential of metabolomics to improve knowledge on the mechanisms involved in shikonin's antitumor action is demonstrated, as well as the potential of metabolic profiling to provide a picture of a cell's phenotype upon intervention, assisting in the elucidation of the mechanism of action.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 90 REFERENCES
Traditional chinese medicine remedy to jury: the pharmacological basis for the use of shikonin as an anticancer therapy.
TLDR
The aim of this review is to report on the most current findings with regard to shikonin's antitumor activity by summarizing and comparing the various studies published in the last ten years and discussing the pharmacological aspects that make shik onin a promising anticancer agent.
Cellular pharmacology studies of shikonin derivatives
TLDR
It is hypothesized that shikonin is an effective inhibitor of protein–protein interaction with multiple targets in both the intracellular and extracellular compartments, which can account for the broad spectrum of shik onin biological and pharmacological activities.
Alkannin and Shikonin: Effect on Free Radical Processes and on Inflammation ‐ A Preliminary Pharmacochemical Investigation
TLDR
It is concluded that the claimed and/or proven actions of alkannin and shikonin are attributable at least partly to their intervention in free radical processes.
Identificación y actividad farmacológica de principios de especies antiinflamatorias.
TLDR
This work studied medicinal plants used such as anti-inflammatory agents in skin diseases in both Chinese traditional medicine and other folk medicines, as well as the antioxidant activity of extracts from Lithospermum erythrorhizon and principles from this species.
Evaluation of the anti-inflammatory and cytotoxic activities of naphthazarine derivatives from Onosma leptantha.
Shikonin, a Component of Chinese Herbal Medicine, Inhibits Chemokine Receptor Function and Suppresses Human Immunodeficiency Virus Type 1
TLDR
Shikonin, as a naturally occurring, low-molecular-weight pan-chemokine receptor inhibitor, constitutes a basis for the development of novel anti-HIV therapeutic agents.
Anti-adenovirus activities of shikonin, a component of Chinese herbal medicine in vitro.
TLDR
The data demonstrate that shikonin possesses anti-AdV3 capabilities and that the potential antiviral mechanism might involve inhibiting the degree of apoptosis and hexon protein expression of AdV.
Alkannins and shikonins: a new class of wound healing agents.
TLDR
The findings and advances on the molecular and biological properties of A/S that promote wound healing are reviewed, revealing a new class of drugs that hold promise as the basis for many valuable therapeutic targets.
The Chemistry and Biology of Alkannin, Shikonin, and Related Naphthazarin Natural Products.
TLDR
Wound healing properties of plant extracts that contain the naphthoquinone natural products alkannin and shikonin have been known for many centuries and their production both by cell cultures and chemical synthesis has been studied extensively.
...
1
2
3
4
5
...