Pharmacological properties of galenical preparation. XVI. Pharmacokinetics of evodiamine and the metabolite in rats.

@article{Komatsu1993PharmacologicalPO,
  title={Pharmacological properties of galenical preparation. XVI. Pharmacokinetics of evodiamine and the metabolite in rats.},
  author={Kazusei Komatsu and Koji Wakame and Yoshihiro Kano},
  journal={Biological & pharmaceutical bulletin},
  year={1993},
  volume={16 9},
  pages={935-8}
}
In an attempt to evaluate its pharmacokinetics, [3H]evodiamine, which is one of the characteristic alkaloids of Evodia fruit was synthesized. The pharmacokinetics of [3H]evodiamine were investigated in rats. In plasma, the main source of radioactivity was a metabolite of d-evodiamine (EM). One hour after oral administration of 200 micrograms/kg of [3H]evodiamine, the radioactivity level in the plasma was maximal. The radioactivity declined in a biphasic manner with half-life times of 1.6 and 78… CONTINUE READING

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