Pharmacological properties of colloidal bismuth subcitrate (CBS, DE-NOL).

@article{Wieriks1982PharmacologicalPO,
  title={Pharmacological properties of colloidal bismuth subcitrate (CBS, DE-NOL).},
  author={Jacob Wieriks and W. Hespe and Kapil Dev Jaitly and P. H. Koekkoek and U. I. Lavy},
  journal={Scandinavian journal of gastroenterology. Supplement},
  year={1982},
  volume={80},
  pages={
          11-6
        }
}
In pharmacological ulcer models in rats colloidal bismuth subcitrate (CBS) demonstrated anti-ulcer activity. This was neither a result of an acid neutralizing nor of an acid secretion inhibitory effect. Both in vitro and in vivo, an anti-peptic action was found. At low pH CBS precipitates and was shown to form a coating on the gastric wall especially on the ulcer crater. This coating most likely forms a protective barrier to the peptic activity of gastric juice. Low toxicity was seen following… CONTINUE READING

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