Pharmacological properties of alpha 9 alpha 10 nicotinic acetylcholine receptors revealed by heterologous expression of subunit chimeras.

@article{Baker2004PharmacologicalPO,
  title={Pharmacological properties of alpha 9 alpha 10 nicotinic acetylcholine receptors revealed by heterologous expression of subunit chimeras.},
  author={Elizabeth Rae Baker and R. T. de Zwart and Emanuele Sher and Neil S Millar},
  journal={Molecular pharmacology},
  year={2004},
  volume={65 2},
  pages={453-60}
}
The nicotinic acetylcholine receptor (nAChR) alpha9 and alpha10 subunits are expressed primarily within hair cells of the inner ear and have been implicated in auditory processing. Although functional recombinant nAChRs generated by the coexpression of alpha9 and alpha10 in Xenopus laevis oocytes have been described previously, there have been no reports of the successful heterologous expression of alpha9alpha10 nAChRs in cultured cell lines. In this study, subunit chimeras (alpha9chi and… CONTINUE READING

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