Pharmacological properties of a new centrally acting muscle relaxant (NC-1200) in isolated muscle preparations.

@article{Takayanagi1988PharmacologicalPO,
  title={Pharmacological properties of a new centrally acting muscle relaxant (NC-1200) in isolated muscle preparations.},
  author={I. Takayanagi and F. Konno and Y. Sato and H. Uno},
  journal={General pharmacology},
  year={1988},
  volume={19 1},
  pages={
          117-21
        }
}
1. Pharmacological properties of a new centrally acting muscle relaxant (NC-1200) were tested in isolated muscle preparations. 2. NC-1200 acted as a Ca-blocker in the guinea pig taenia caecum. The pA2-value was 5.67. 3. In the rabbit aorta, NC-1200 competed with serotonin at serotonin receptors and also shifted the concentration response curves of histamine and norepinephrine suggesting the possibility that NC-1200 interacted with histamine and norepinephrine receptors. The pA2-value of NC-1200… Expand
2 Citations
Some pharmacological properties of a new antitumor drug, CPT-11, in isolated muscle preparations.
TLDR
Results suggest that CPT-11 has an acetylcholine action, and the chronic and inotropic effects induced by isoprenaline were depressed by C PT-11. Expand
Inhibitory effects of a new, potent, centrally acting muscle relaxant, (4S,5R)-4-(2-methylpropyl)-3-[3-(perhydroazepin-1-yl)propyl]-5- phenyl-1,3-oxazolidin-2-one (NC-1200) on micturition contractions of the bladder in rats.
TLDR
It is concluded that NC- 1200 inhibits the micturition contraction by inhibiting pelvic efferent nerve activity and that this inhibitory effect of NC-1200 originates mainly in the central nervous system. Expand

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