Pharmacological properties of a new centrally acting muscle relaxant (NC-1200) in isolated muscle preparations.

  title={Pharmacological properties of a new centrally acting muscle relaxant (NC-1200) in isolated muscle preparations.},
  author={I. Takayanagi and F. Konno and Y. Sato and H. Uno},
  journal={General pharmacology},
  volume={19 1},
1. Pharmacological properties of a new centrally acting muscle relaxant (NC-1200) were tested in isolated muscle preparations. 2. NC-1200 acted as a Ca-blocker in the guinea pig taenia caecum. The pA2-value was 5.67. 3. In the rabbit aorta, NC-1200 competed with serotonin at serotonin receptors and also shifted the concentration response curves of histamine and norepinephrine suggesting the possibility that NC-1200 interacted with histamine and norepinephrine receptors. The pA2-value of NC-1200… Expand
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