Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization.

@article{Romero2012PharmacologicalPO,
  title={Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization.},
  author={L. Enrique Romero and Daniel Zamanillo and Xavier Nadal and Ricard S{\'a}nchez-Arroyos and Ivan Rivera-Arconada and Alberto Dordal and Ana Belen Santos Montero and Asunci{\'o}n Muro and Alessandra Bura and C Segal{\'e}s and M Laloya and Elen Hernandez and Enrique F Portillo-Salido and Marisol Escriche and Xavier Codony and G Encina and Javier Burgue{\~n}o and Manuel Merlos and Jos{\'e} Manuel Baeyens and Jes{\'u}s Giraldo and Jose A Lopez-Garcia and Rafael Maldonado and Carlos Plata-Salam{\'a}n and Jos{\'e} Miguel Vela},
  journal={British journal of pharmacology},
  year={2012},
  volume={166 8},
  pages={2289-306}
}
BACKGROUND AND PURPOSE The sigma-1 (σ(1) ) receptor is a ligand-regulated molecular chaperone that has been involved in pain, but there is limited understanding of the actions associated with its pharmacological modulation. Indeed, the selectivity and pharmacological properties of σ(1) receptor ligands used as pharmacological tools are unclear and the demonstration that σ(1) receptor antagonists have efficacy in reversing central sensitization-related pain sensitivity is still missing… CONTINUE READING
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