Pharmacological profile of ramosetron, a novel therapeutic agent for IBS
@article{Hirata2006PharmacologicalPO, title={Pharmacological profile of ramosetron, a novel therapeutic agent for IBS}, author={T. Hirata and T. Funatsu and Y. Keto and M. Nakata and M. Sasamata}, journal={Inflammopharmacology}, year={2006}, volume={15}, pages={5-9} }
Abstract.Ramosetron is a potent and selective serotonin (5-HT)3 receptor antagonist that has been shown to affect abnormal colonic function and abdominal pain in animals. Ramosetron (0.3 to 100 µg/kg, p.o.) has been found to significantly suppress abnormal defecation induced by conditioned-fear stress (CFS), restraint stress, corticotropin releasing factor (CRF) and 5-HT in rats and mice, and these effects were more potent than those of alosetron, cilansetron or loperamide. On the other hand… CONTINUE READING
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