Pharmacological profile of ramosetron, a novel therapeutic agent for IBS

  title={Pharmacological profile of ramosetron, a novel therapeutic agent for IBS},
  author={T. Hirata and T. Funatsu and Y. Keto and M. Nakata and M. Sasamata},
  • T. Hirata, T. Funatsu, +2 authors M. Sasamata
  • Published 2006
  • Medicine
  • Inflammopharmacology
  • Abstract.Ramosetron is a potent and selective serotonin (5-HT)3 receptor antagonist that has been shown to affect abnormal colonic function and abdominal pain in animals. Ramosetron (0.3 to 100 µg/kg, p.o.) has been found to significantly suppress abnormal defecation induced by conditioned-fear stress (CFS), restraint stress, corticotropin releasing factor (CRF) and 5-HT in rats and mice, and these effects were more potent than those of alosetron, cilansetron or loperamide. On the other hand… CONTINUE READING
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