Pharmacological profile of a novel H(2)S-releasing aspirin.

@article{Sparatore2009PharmacologicalPO,
  title={Pharmacological profile of a novel H(2)S-releasing aspirin.},
  author={A. Sparatore and E. Perrino and Valerio Tazzari and D. Giustarini and R. Rossi and G. Rossoni and K. Erdmann and Henning Schr{\"o}der and P. del Soldato},
  journal={Free radical biology & medicine},
  year={2009},
  volume={46 5},
  pages={
          586-92
        }
}
  • A. Sparatore, E. Perrino, +6 authors P. del Soldato
  • Published 2009
  • Medicine, Chemistry
  • Free radical biology & medicine
  • The pharmacological profile of a new, safe, and effective hydrogen sulfide (H(2)S)-releasing derivative of aspirin (ACS14) is described. We report the synthesis of ACS14, and of its deacetylated metabolite (ACS21), the preliminary pharmacokinetics, and its in vivo metabolism, with the H(2)S plasma levels after intravenous administration in the rat. ACS14 maintains the thromboxane-suppressing activity of the parent compound, but seems to spare the gastric mucosa, by affecting redox imbalance… CONTINUE READING

    Figures, Tables, and Topics from this paper.

    Hydrogen sulphide: novel opportunity for drug discovery.
    116
    Medical Functions of Hydrogen Sulfide.
    3
    Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs
    11

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 36 REFERENCES
    NO-aspirins: a class of new anti-inflammatory and antithrombotic agents.
    145
    Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative.
    275
    Hydrogen sulphide and its therapeutic potential
    1290
    Heme oxygenase-1 is a novel target and antioxidant mediator of S-adenosylmethionine.
    15
    Hydrogen sulfide is a novel mediator of lipopolysaccharide‐induced inflammation in the mouse
    627
    Heme oxygenase-1 induction may explain the antioxidant profile of aspirin.
    137
    A new gaseous signaling molecule emerges: Cardioprotective role of hydrogen sulfide
    239
    Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications.
    1820