Pharmacological profile of a novel, orally active leukotriene B4 antagonist, SM-15178

Abstract

SM-15178, a new hydroxyacetophenone derivative, was evaluated to determine its antiinflammatory activity and antagonistic activity against leukotriene B4 (LTB4). SM-15178 inhibited [3H]LTB4 binding to its receptors on human neutrophils (IC50=0.30μM). It inhibited LTB4-induced chemotaxis of human neutrophils (IC50 =0.72μM) with little inhibitory effect… (More)
DOI: 10.1007/BF01534554

Topics

8 Figures and Tables

Cite this paper

@article{Ohmi1994PharmacologicalPO, title={Pharmacological profile of a novel, orally active leukotriene B4 antagonist, SM-15178}, author={Naoko Ohmi and Chiemi Tani and Kimiko A Yamada and Masaru Fukui}, journal={Inflammation}, year={1994}, volume={18}, pages={129-140} }