Pharmacological profile of a 17β-heteroaryl-substituted neuroactive steroid

@article{Hogenkamp2014PharmacologicalPO,
  title={Pharmacological profile of a 17$\beta$-heteroaryl-substituted neuroactive steroid},
  author={Derk J. Hogenkamp and Minhtam B. Tran and Ryan F. Yoshimura and Timothy B C Johnstone and Richard C. Kanner and Kelvin W. Gee},
  journal={Psychopharmacology},
  year={2014},
  volume={231},
  pages={3517-3524}
}
RationaleIn order to improve upon the pharmacological properties of the neuroactive steroid ganaxolone, it was used as the starting point in the design of novel neurosteroids that replace the 17β-acetyl side chain with an isoxazole bioisostere.ObjectivesUCI-50027 (3-[3α-hydroxy-3β-methyl-5α-androstan-17β-yl]-5-(hydroxymethyl)isoxazole) was designed as an orally active neuroactive steroid specifically targeted at the gamma-aminobutyric acid(A) receptor (GABAAR).MethodsUCI-50027 was tested in… 
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