• Corpus ID: 45961850

Pharmacological profile of NPC 12626, a novel, competitive N-methyl-D-aspartate receptor antagonist.

@article{Ferkany1989PharmacologicalPO,
  title={Pharmacological profile of NPC 12626, a novel, competitive N-methyl-D-aspartate receptor antagonist.},
  author={John Wm. Ferkany and Donald J. Kyle and J M Willets and Waclaw J. Rzeszotarski and M. E. Guzewska and Suzanne R. Ellenberger and S. M. Jones and Aida I. Sacaan and Lawrence D. Snell and Susan A. Borosky},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1989},
  volume={250 1},
  pages={
          100-9
        }
}
  • J. Ferkany, D. Kyle, S. Borosky
  • Published 1 July 1989
  • Biology, Chemistry
  • The Journal of pharmacology and experimental therapeutics
The novel compound 2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid (NPC 12626) was evaluated for activity in a variety of tests associated with receptors for excitatory amino acids. NPC 12626 failed to inhibit the specific binding of RS-[3H] amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid or [3H] kainic acid to brain membranes in vitro but displaced both agonist and antagonist binding to N-methyl-D-aspartic acid (NMDA) receptors. Like cis-(+/-)-3-(2-carboxypiperazine-4-yl)propyl-1… 
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