Pharmacological principles as a basis for polytherapy.

  title={Pharmacological principles as a basis for polytherapy.},
  author={Emilio Perucca},
  journal={Acta neurologica Scandinavica. Supplementum},
  • Emilio Perucca
  • Published 1995 in Acta neurologica Scandinavica. Supplementum
Most patients with newly diagnosed epilepsy can be optimally controlled by prescribing a single anti-epilepsy drug, selected on the basis of its efficacy and safety profile. In about one-third of patients, however, seizures persist during monotherapy, despite the intake of the maximally tolerated drug dose. In such cases, substantial therapeutic benefit may be achieved by prescribing appropriate drug combinations. Safe use of multiple drug therapy requires a good knowledge of clinical… CONTINUE READING

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