Pharmacological preconditioning with low-dose cyclosporine or FK506 reduces subsequent ischemia/reperfusion injury in rat kidney.

@article{Yang2001PharmacologicalPW,
  title={Pharmacological preconditioning with low-dose cyclosporine or FK506 reduces subsequent ischemia/reperfusion injury in rat kidney.},
  author={Chul Woo Yang and Hee Jong Ahn and Ho Jae Han and Wan Young Kim and Can Li and Mi Jung Shin and Soon Kyum Kim and Joo Hyun Park and Yeon-Hee Kim and I S Moon and Byung Kee Bang},
  journal={Transplantation},
  year={2001},
  volume={72 11},
  pages={1753-9}
}
BACKGROUND Ischemia/reperfusion (I/R) injury in the early posttransplant period is closely associated with delayed recovery of graft function, increased acute rejection, and late allograft dysfunction. Pharmacological preconditioning with low-dose cyclosporine (CsA) or FK506 was performed to induce ischemic tolerance in rat kidney with I/R injury. METHODS Low-dose CsA (3 mg/kg, administered i.v.) or FK506 (0.3 mg/kg i.v.) were used to induce ischemic tolerance in Sprague-Dawley rats, and the… CONTINUE READING

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