Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition.

  title={Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition.},
  author={Michelle Batthish and Roberto J Diaz and He-ping Zeng and Peter Backx and Gregory J. Wilson},
  journal={Cardiovascular research},
  volume={55 3},
OBJECTIVES We have recently proposed that chloride (Cl(-)) channels contribute to ischemic preconditioning (IPC) in the myocardium. To further evaluate this hypothesis, we investigated the role of Cl(-) channels in pharmacological preconditioning. METHODS Isolated rabbit cardiomyocytes and isolated buffer-perfused rabbit hearts were initially preconditioned with a 10 min exposure to either an adenosine receptor agonist [2-chloro-N(6)-cyclopentyladenosine (CCPA, 200 nM) and/or N(6)-2-(4… CONTINUE READING


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