Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition.

@article{Batthish2002PharmacologicalPI,
  title={Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition.},
  author={Michelle Batthish and Roberto J Diaz and He-ping Zeng and Peter Backx and Gregory J. Wilson},
  journal={Cardiovascular research},
  year={2002},
  volume={55 3},
  pages={660-71}
}
OBJECTIVES We have recently proposed that chloride (Cl(-)) channels contribute to ischemic preconditioning (IPC) in the myocardium. To further evaluate this hypothesis, we investigated the role of Cl(-) channels in pharmacological preconditioning. METHODS Isolated rabbit cardiomyocytes and isolated buffer-perfused rabbit hearts were initially preconditioned with a 10 min exposure to either an adenosine receptor agonist [2-chloro-N(6)-cyclopentyladenosine (CCPA, 200 nM) and/or N(6)-2-(4… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Protein kinase2 infarction afforded by preconditioning is mediated by A 1 adenosinedependent Cl currents in feline ventricular myocytes . Circ Res receptors in rabbit heart

  • GS Liu, J Thornton, +4 authors RE TenEick
  • Circulation
  • 2001

Protein tyrosine kinase inhibitors okadaic acid and calyculin A on metabolically inhibited is downstream of protein kinase C for ischemic preconditioning ’ s and ischemic isolated myocytes

  • SC Armstrong, CE Ganote, CP Baines, L Wang, MV Cohen, JM Downey
  • J Mol Cell Cardiol
  • 2001

Adenosine receptor specificity in preprotein kinase C activity

  • S Armstrong, CE Ganote
  • Circ Res
  • 1999

Preconditioning of isolated rabbit car1 2 and K – Cl costransport in the regulatory volume decrease of diomyocytes : effects of glycolytic blockade , phorbol esters , and newborn rat cardiomyocytes

  • K Taouil, P Hannaert, S Armstrong, CE Ganote
  • Pflugers Arch
  • 1999

An irreversible Aselective 1 receptor involvement

  • Liu G-S, KA Jacobson, JM Downey
  • Cardiovasc Res
  • 1997

Similar Papers

Loading similar papers…