Pharmacological postconditioning with diazoxide attenuates ischemia/reperfusion-induced injury in rat liver

@inproceedings{TIAN2013PharmacologicalPW,
  title={Pharmacological postconditioning with diazoxide attenuates ischemia/reperfusion-induced injury in rat liver},
  author={Y. S. TIAN and T. Z. RONG and Y. L. HONG and Lian-qiu Min and P. G. JIAN},
  booktitle={Experimental and therapeutic medicine},
  year={2013}
}
It has been demonstrated that ischemic postconditioning (IPO) is capable of attenuating ischemia/reperfusion (I/R) injury in the heart. However, the novel role of pharmacological postconditioning in the liver remains unclear. In this study, the hypothesis that diazoxide postconditioning reduces I/R-induced injury in rat liver was tested. Rats were assigned randomly to the sham-operated control, I/R (occlusion of the porta hepatis for 60 min, followed by a persistent reperfusion for 120 min… CONTINUE READING

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