Pharmacological modulation of transmitter release by inhibition of pressure-dependent potassium currents in vestibular hair cells

@article{Haasler2009PharmacologicalMO,
  title={Pharmacological modulation of transmitter release by inhibition of pressure-dependent potassium currents in vestibular hair cells},
  author={Thorsten Haasler and Georg Homann and Thien An Duong Dinh and Eberhard Jüngling and Martin Westhofen and Andreas Lückhoff},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2009},
  volume={380},
  pages={531-538}
}
Vestibular vertigo may be induced by increases in the endolymphatic pressure that activate pressure-dependent K+ currents (IK,p) in vestibular hair cells. IK,p have been demonstrated to modulate transmitter release and are inhibited by low concentrations of cinnarizine. Beneficial effects against vestibular vertigo of cinnarizine have been attributed to its inhibition of calcium currents. Our aim was to determine the extent by which the inhibition of IK,p by cinnarizine may alter the voltage… 

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