Pharmacological modulation of the endocannabinoid system in a viral model of multiple sclerosis.

@article{Mestre2005PharmacologicalMO,
  title={Pharmacological modulation of the endocannabinoid system in a viral model of multiple sclerosis.},
  author={Leyre Mestre and Fernando Pe{\~n}aranda Correa and Angel Ar{\'e}valo-Mart{\'i}n and Eduardo Molina-Holgado and Marta Valenti and Giorgio Ortar and Vincenzo Di Marzo and Carmen Guaza},
  journal={Journal of neurochemistry},
  year={2005},
  volume={92 6},
  pages={1327-39}
}
Theiler's virus infection of the central nervous system (CNS) induces an immune-mediated demyelinating disease in susceptible mouse strains and serves as a relevant infection model for human multiple sclerosis (MS). Cannabinoids have been shown to exert beneficial effects on animal models of MS and evidence suggests that the endocannabinoid system plays a role in the tonic control of spasticity. In this study we show that OMDM1 [(R)-N-oleoyl-(1'-hydroxybenzyl)-2'-ethanolamine] and OMDM2 [(S)-N… CONTINUE READING