Pharmacological modulation of secondary mediator systems–cyclic AMP and cyclic GMP–on inflammatory hyperalgesia

@article{Cunha1999PharmacologicalMO,
  title={Pharmacological modulation of secondary mediator systems–cyclic AMP and cyclic GMP–on inflammatory hyperalgesia},
  author={Fernando de Q Cunha and M. Menossi Teixera and Sérgio Henrique Ferreira},
  journal={British Journal of Pharmacology},
  year={1999},
  volume={127}
}
The objective of the present paper was to evaluate the relevance of neuronal balance of cyclic AMP and cyclic GMP concentration for functional regulation of nociceptor sensitivity during inflammation. Injection of PGE2 (10–100 ng paw−1) evoked a dose‐dependent hyperalgesic effect which was mediated via a cyclic AMP‐activated protein kinase (PKA) inasmuch as hyperalgesia was blocked by the PKA inhibitor H89. The PDE4 inhibitor rolipram and RP73401, but not PDE3 and PDE5 inhibitors potentiated… 

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