Pharmacological modulation of human platelet leukotriene C4-synthase.

  title={Pharmacological modulation of human platelet leukotriene C4-synthase.},
  author={Angelo Sala and Giancarlo Folco and Peter M Henson and Robert C. Murphy},
  journal={Biochemical pharmacology},
  volume={53 6},
The aim of this study was to test if human platelet leukotriene C4-synthase (LTC4-S) is pharmacologically different from cloned and expressed LTC4-S and, in light of the significant homologies between 5-lipoxygenase activating protein (FLAP) and LTC4-S, if different potencies of leukotriene synthesis inhibitors acting through binding with FLAP (FLAP inhibitors) reflect in different potencies as LTC4-S inhibitors. Leukotriene C4 (LTC4) synthesis by washed human platelets supplemented with… CONTINUE READING

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