Pharmacological modulation of caspase-8 in thymus-related medical conditions.


The thymus is a lymphoid organ that governs the development of a diverse T-cell repertoire capable of defending against nonself-antigens and avoiding autoimmunity. However, the thymus can also succumb to different diseases. Hypertrophic diseases, such as thymomas, are typically associated with impairment of negative selection, which leads to autoimmune… (More)
DOI: 10.1124/jpet.114.216572


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